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This scenario prompted us to investigate the correlation between mast cell degranulation and neutrophil influx within the digits and knees joints of arthritic mice assessing what could be the functional role(s) of joint mast cells in the response to collagen immunization

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To examine the nitric oxide-dependency in this system, the rings were pretreated with 0.03 mM L-NAME, an eNOS inhibitor or 10 M hemoglobin, a nitric oxide scavenger